GastroPlus includes:

• Physiological models for human (fasted and fed), beagle dog (fasted and fed), rat, mouse, rabbit and cat
• Peff converter to convert user-measured permeability to human in vivo Peff
• pH-dependent solubility and logD models
• Dissolution dependence on particle size and particle density
• One-, two-, or three-compartment pharmacokinetics
• Controlled release dosage forms including gastric retention, dispersed release and integral tablet
• Automatic model fitting and formulation design (with optional Optimization Module)
• Saturable gut & liver metabolism and gut transport (with optional Metabolism and Transporter Module)
• Ability to simultaneously fit pharmacokinetic parameters to IV and oral data
• In Vitro - In Vivo Correlation (with optional IVIV Correlation Module)