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Clinical Evidence Description
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Fitting interventions into these categories is not always
straightforward. For one thing, the categories represent a
mix of several hierarchies: the level of benefit (or harm),
the level of evidence (RCT or observational data), and the
level of certainty around the finding (represented by the
confidence interval).
Another problem is that much of the
evidence that is most relevant to clinical decisions relates
to comparisons between different interventions rather than
to comparison with placebo or no intervention. Where necessary,
we have indicated the comparisons. A third problem is that
interventions may have been tested, or found to be effective,
in only one group of people, such as those at high risk of
an outcome. Again, we have indicated this where possible.
But perhaps most difficult of all has been trying to maintain
consistency across different topics. We are working on refining
the criteria for putting interventions under each category.
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